SCHEMBL28198501

SCHEMBL28198501

CC(C)(C)OC(=O)NCCCCC(N)C(=O)OCc1ccccc1.CS(=O)(=O)O

nearest known ligand 0.56

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.56
DPP8 Q6V1X1 3/20 0.53
DPP7 Q9UHL4 3/20 0.53
ANPEP P15144 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.51
DPP4 P27487 2/20 0.50
DPP9 Q86TI2 2/20 0.50
SYK P43405 1/20 0.50
POLB P06746 1/20 0.49
MAPK1 P28482 1/20 0.49
KLK7 P49862 1/20 0.49
KLK5 Q9Y337 1/20 0.49
MEN1 O00255 1/20 0.48
RECQL P46063 1/20 0.48
KMT2A Q03164 1/20 0.48
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
MMP2 P08253 2/20 0.48
MMP9 P14780 2/20 0.48
SLC1A3 P43003 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28251423 1.00 MAPT (0.56) MAPTDPP8DPP7ANPEPL3MBTL1
SCHEMBL5490556 0.97 MAPT (0.59) MAPTDPP8DPP7ANPEPL3MBTL1
SCHEMBL20168169 0.97 MAPT (0.59) MAPTDPP8DPP7ANPEPL3MBTL1
SCHEMBL7979181 0.97 MAPT (0.59) MAPTDPP8DPP7ANPEPL3MBTL1
Hydrochloric Acid SCHEMBL29401553 0.96 MAPT (0.58) MAPTDPP8DPP7ANPEPL3MBTL1
SCHEMBL21164376 0.93 MAPT (0.55) MAPTDPP8DPP7ANPEPL3MBTL1
Hydrochloric Acid SCHEMBL29401089 0.92 MAPT (0.54) MAPTDPP8DPP7ANPEPL3MBTL1
SCHEMBL17878734 0.89 SYK (0.56) MAPTDPP8DPP7L3MBTL1SYK
SCHEMBL3824366 0.88 MAPT (0.56) MAPTDPP8DPP7ANPEPL3MBTL1
SCHEMBL7295558 0.88 MAPT (0.56) MAPTDPP8DPP7ANPEPL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110621700-B Method for GalNAc oligonucleotide conjugates 豪夫迈·罗氏有限公司 2023-08-18 CN disclosed
CN-108738321-B GalNAc cluster phosphoramidites 豪夫迈·罗氏有限公司 2021-06-11 CN disclosed
CN-108738321-A9 GalNAc cluster phosphoramidites 豪夫迈·罗氏有限公司 2021-01-29 CN disclosed
CN-107709342-A Process for preparing acetylgalactosamine acid derivatives 豪夫迈·罗氏有限公司 2018-02-16 CN disclosed