Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3212255 | 0.82 | RAPGEF4 (0.60) | RAPGEF4ALDH1A1LMNAFFAR4 | |
| Hydrochloric Acid SCHEMBL2071013 | 0.80 | RAPGEF4 (0.57) | RAPGEF4ALDH1A1LMNAFFAR4 | |
| Sulfuric Acid SCHEMBL28200703 | 0.79 | RAPGEF4 (0.46) | RAPGEF4ALDH1A1GAALMNAFFAR4 | |
| Nitric Acid SCHEMBL28348863 | 0.75 | TSHR (0.62) | ALDH1A1GAALMNAGPR35TSHR | |
| SCHEMBL11688261 | 0.69 | TDP1 (0.39) | ALDH1A1GAALMNATSHRCYP3A4 | |
| SCHEMBL11774357 | 0.68 | RAPGEF4 (0.53) | RAPGEF4ALDH1A1HPGDLMNATSHR | |
| SCHEMBL11334768 | 0.68 | RAPGEF4 (0.48) | RAPGEF4ALDH1A1LMNA | |
| Nitric Acid SCHEMBL20984881 | 0.68 | KMT2A (0.39) | RAPGEF4ALDH1A1GAALMNAMEN1 | |
| Nitric Acid SCHEMBL20985017 | 0.68 | ALDH1A1 (0.47) | ALDH1A1GAAHPGDLMNATSHR | |
| Nitric Acid SCHEMBL20984069 | 0.68 | CYP3A4 (0.34) | ALDH1A1GAATSHRCYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107663161-A | A kind of continuous stream synthesis technique of phenylhydrazine salt and substituted benzene hydrazonium salt | 上海惠和化德生物科技有限公司 | 2018-02-06 | — | — | CN | disclosed |