Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 8/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | CLK1 | P49759 | 3/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.49 |
| ▸ | CCNK | O75909 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318366 | 0.98 | FGFR1 (0.55) | FGFR1MAPK1CLK4DYRK1ACLK1 | |
| SCHEMBL27976107 | 0.77 | CLK1 (0.74) | FGFR1MAPK1CLK4DYRK1ACLK1 | |
| SCHEMBL18151250 | 0.77 | TRPA1 (0.51) | FGFR1CLK4DYRK1ACLK1FGFR2 | |
| SCHEMBL29445919 | 0.76 | BRAF (0.47) | ABL1SRCKDRDYRK1BBRAF | |
| SCHEMBL18151247 | 0.76 | TRPA1 (0.47) | FGFR1MAPK1CLK4DYRK1ACLK1 | |
| SCHEMBL28727101 | 0.76 | CDK2 (0.61) | FGFR1MAPK1CLK4DYRK1ACLK1 | |
| SCHEMBL29481911 | 0.76 | KDM4E (0.51) | FGFR1MAPK1CLK4DYRK1AFGFR2 | |
| SCHEMBL28727178 | 0.76 | KDM4E (0.51) | FGFR1MAPK1CLK4DYRK1AFGFR2 | |
| SCHEMBL29481882 | 0.76 | CDK2 (0.61) | FGFR1MAPK1CLK4DYRK1ACLK1 | |
| SCHEMBL29481878 | 0.76 | CDK2 (0.61) | FGFR1MAPK1CLK4DYRK1ACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107721991-B | A kind of 6- (pyrimidine-4-yl) -1H- indazole derivative and its preparation method and application | 南方医科大学中西医结合医院 | 2019-10-18 | — | — | CN | claimed |
| CN-107721991-A | A kind of 6 (base of pyrimidine 4) 1H indazole derivatives and its preparation method and application | 南方医科大学中西医结合医院 | 2018-02-23 | — | — | CN | claimed |