Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28200954 | 1.00 | CTSK (0.43) | CTSKKMT2ATSHRHSD17B10CA1 | |
| SCHEMBL27509373 | 0.78 | ATM (0.54) | CTSKKMT2ATSHRHSD17B10CTSS | |
| SCHEMBL12203593 | 0.78 | CTSK (0.62) | CTSKKMT2AHSD17B10CTSSATM | |
| SCHEMBL6346032 | 0.78 | CTSK (0.62) | CTSKKMT2AHSD17B10CTSSATM | |
| SCHEMBL6346030 | 0.78 | CTSK (0.62) | CTSKKMT2AHSD17B10CTSSATM | |
| SCHEMBL23205455 | 0.76 | GPR139 (0.48) | CTSKKMT2ATSHRHSD17B10CA1 | |
| SCHEMBL13542547 | 0.76 | GPR139 (0.48) | CTSKKMT2ATSHRHSD17B10CA1 | |
| SCHEMBL3502878 | 0.76 | CTSK (0.48) | CTSKKMT2ATSHRHSD17B10CA1 | |
| SCHEMBL15048272 | 0.76 | CTSK (0.48) | CTSKKMT2ATSHRHSD17B10CA1 | |
| SCHEMBL25546987 | 0.76 | GPR139 (0.48) | CTSKKMT2ATSHRHSD17B10CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105263935-B | 6, 7-dihydropyrazolo [1,5-a ] pyrazin-4 (5H) -one compounds and their use as negative allosteric modulators of the MG L UR2 receptor | 詹森药业有限公司 | 2018-02-27 | — | — | CN | disclosed |