Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL384976 | 0.98 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL28148628 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL28657879 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL28868894 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL8015717 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL29157615 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL1146498 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL9538173 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL27660948 | 0.94 | ALDH1A1 (0.62) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL16164747 | 0.94 | ALDH1A1 (0.62) | ALDH1A1TSHRLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805992-B1 | Concentrate for preparing a sealing solution for sealing mail pieces using tap water and method of making same | PITNEY BOWES INC (US) | 2018-09-05 | — | — | EP | claimed |
| CN-103454327-B | P3MT/N-GE modified glassy carbon electrode and the application in detection pesticide phoxim | NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-01-20 | — | — | CN | claimed |
| CN-103454326-B | P3MT/GE modified glassy carbon electrode and the application at detection of drugs paracetamol | NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-12-02 | — | — | CN | claimed |
| CN-103183977-B | As the hollow glass microballoon being coated with the nano titanium oxide of doped with metal elements, the preparation method and its usage of paint filler | JIANGSU KFCC NEW MATERIALS Co.,Ltd. (CN) | 2015-11-11 | — | — | CN | claimed |
| CN-103454331-B | Peroxidating PEDOT/GO modified electrode and the electrochemical detection method to pesticide imidacloprid thereof | NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-09-30 | — | — | CN | claimed |
| CN-103720642-B | A kind of externally used solution containing bioprotein and preparation method thereof | BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) | 2015-09-16 | — | — | CN | claimed |
| US-9057005-B2 | Concentrate for preparing a sealing solution for sealing mail pieces using tap water and method of making same | PITNEY BOWES INC. (US) | 2015-06-16 | — | — | US | claimed |
| CN-103454333-B | Electrochemical detection method for pesticide imidacloprid based on polypyrrole/reduced graphene oxide (PPy/RGO) modified glassy carbon electrode | UNIV NANJING SCIENCE & TECH | 2015-05-13 | — | — | CN | claimed |
| CN-103454332-B | Electrochemical method used for rapidly detecting imidacloprid serving as pesticide | UNIV NANJING SCIENCE & TECH | 2015-05-13 | — | — | CN | claimed |
| EP-2805992-A1 | Concentrate for preparing a sealing solution for sealing mail pieces using tap water and method of making same | Pitney Bowes Inc. (US) | 2014-11-26 | — | — | EP | claimed |
| CN-103604858-A | Electrochemical detection method of acetaminophen medicine by PEDOT (Polymer Ethylenedioxy Thiophene)/GO (Graphene Oxide)/GCE (Glassy Carbon Electrode) | UNIV NANJING SCIENCE & TECH | 2014-02-26 | — | — | CN | claimed |
| CN-103499629-A | Electrochemical method for detecting explosive HMX | UNIV NANJING SCIENCE & TECH | 2014-01-08 | — | — | CN | claimed |
| CN-103472120-A | Electrochemical method for detecting pesticide phoxim | UNIV NANJING SCIENCE & TECH | 2013-12-25 | — | — | CN | claimed |
| CN-103454333-A | Electrochemical detection method for pesticide imidacloprid based on polypyrrole/reduced graphene oxide (PPy/RGO) modified glassy carbon electrode | UNIV NANJING SCIENCE & TECH | 2013-12-18 | — | — | CN | claimed |
| CN-103454326-A | Poly-3-methyl thiophene-graphene (P3MT/GE) modified glassy carbon electrode and application thereof to detecting medicine paracetamol | UNIV NANJING SCIENCE & TECH | 2013-12-18 | — | — | CN | claimed |
| CN-103454331-A | Per-oxidized poly(3,4-ethylenedioxythiophene-graphite oxide (PEDOT/GO) modified electrode and electrochemical detection method thereof to pesticide imidacloprid | UNIV NANJING SCIENCE & TECH | 2013-12-18 | — | — | CN | claimed |
| CN-103454327-A | Poly-3-methyl thiophene-N-doped graphene (P3MT/N-GE) modified glassy carbon electrode and application thereof to detecting pesticide phoxim | UNIV NANJING SCIENCE & TECH | 2013-12-18 | — | — | CN | claimed |
| CN-103454332-A | Electrochemical method used for rapidly detecting imidacloprid serving as pesticide | UNIV NANJING SCIENCE & TECH | 2013-12-18 | — | — | CN | claimed |
| CN-103183977-A | Hollow glass microsphere coated with nanometer titania doped with metallic elements and serving as coating padding, preparation method and application thereof | JIANGSU KAOPULE NEW MATERIALS CO LTD | 2013-07-03 | — | — | CN | claimed |
| CN-101198313-A | Pharmaceutical formulations comprising a long-acting beta2-agonist for administration by nebulisation | CHIESI FARMA SPA (IT) | 2008-06-11 | — | — | CN | claimed |