Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL2820103 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL28657879 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL29157615 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL28148628 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL8015717 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL1146498 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL9538173 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL28868894 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL27660948 | 0.96 | ALDH1A1 (0.62) | ALDH1A1TSHRLMNAKMT2AMEN1 | |
| Citric Acid SCHEMBL16164747 | 0.96 | ALDH1A1 (0.62) | ALDH1A1TSHRLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5323 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116725222-B | Method for improving tobacco stalk quality by using ganoderma lucidum fermentation liquor and cellulase composite preparation | 四川中烟工业有限责任公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122060552-A | Technological method for extracting basswood ganoderma lucidum spore essential oil with assistance of ultrasonic enzyme | 荆楚理工学院 | 2026-05-19 | — | — | CN | claimed |
| CN-122005375-A | High-stability antiallergic collagen-chamomile active component hydrogel and large-scale preparation method and application thereof | 自然资源部第三海洋研究所 | 2026-05-12 | — | — | CN | claimed |
| CN-121574837-A | Pichia pastoris culture medium and fermentation method | 西藏天虹科技股份有限责任公司 | 2026-02-27 | — | — | CN | claimed |
| CN-120192355-A | A method for preparing trilobatin from hesperidin | 陕西嘉禾生物科技股份有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-117229159-B | Nitrite detection method | 四川大学 | 2025-06-24 | — | — | CN | claimed |
| CN-115976114-B | Method for realizing resource utilization of frying waste oil based on starch-based Pickering emulsion system | 江南大学 | 2025-06-24 | — | — | CN | claimed |
| CN-120158945-A | One-bath dyeing process for polyester cotton | 浙江爱利斯染整有限公司 | 2025-06-17 | — | — | CN | claimed |
| CN-120130470-A | Processing method for quick dyeing and fresh-keeping cooperative treatment of cut flowers of starfish and special preparation | 云南花益美生物科技有限责任公司 | 2025-06-13 | — | — | CN | claimed |
| CN-120133296-A | Method for removing heavy metals in fly ash | 长沙稷下科技咨询有限公司 | 2025-06-13 | — | — | CN | claimed |
| US-5746838-A | TIME-RELEASE ENZYME DEACTIVATION | ALLERGAN (US) | 1998-05-05 | — | — | US | claimed |
| EP-0502504-B1 | A biosensor utilizing enzyme and a method for producing the same | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 1997-07-02 | — | — | EP | claimed |
| EP-0435012-B1 | 2-part hair dyeing agent | SUNSTAR KK (JP) | 1994-04-27 | — | — | EP | claimed |
| US-5192415-A | Biosensor utilizing enzyme and a method for producing the same | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1993-03-09 | — | — | US | claimed |
| EP-0502504-A1 | A biosensor utilizing enzyme and a method for producing the same | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1992-09-09 | — | — | EP | claimed |
| US-5131912-A | Compound capable of forming bicarbonate by dissociation in water, alkali generating no irritating odor, hydrogen peroxide, buffer solution; ph control | SUNSTAR KABUSHIKI KAISHA (JP) | 1992-07-21 | — | — | US | claimed |
| EP-0435012-A1 | 2-part hair dyeing agent | SUNSTAR KABUSHIKI KAISHA (JP) | 1991-07-03 | — | — | EP | claimed |
| CN-1052043-A | 2-PART HAIR DYEING AGENTS | SUNSTAR KK (JP) | 1991-06-12 | — | — | CN | claimed |
| US-4290910-A | CONTROLLING PH, AMINE, BUFFER | TANABE SEIYAKU CO., LTD. (JP) | 1981-09-22 | — | — | US | claimed |
| US-4214888-A | Foliar fertilization method and composition | UNION OIL COMPANY OF CALIFORNIA (US) | 1980-07-29 | — | — | US | claimed |