Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.53 |
| ▸ | CLK1 | P49759 | 4/20 | 0.53 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | CLK2 | P49760 | 4/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CLK3 | P49761 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
| ▸ | CCND1 | P24385 | 3/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28200962 | 0.86 | DYRK1A (0.53) | DYRK1ACLK4CLK1CDK2CLK2 | |
| SCHEMBL28856408 | 0.82 | DYRK1A (0.64) | DYRK1ACLK4CLK1CDK2CLK2 | |
| SCHEMBL28200945 | 0.81 | DYRK1A (0.54) | DYRK1ACLK4CLK1CDK2CLK2 | |
| SCHEMBL29481867 | 0.80 | DYRK1A (0.62) | DYRK1ACLK4CLK1CDK2CLK2 | |
| SCHEMBL28727089 | 0.80 | DYRK1A (0.62) | DYRK1ACLK4CLK1CDK2CLK2 | |
| SCHEMBL28201523 | 0.78 | DYRK1A (0.52) | DYRK1ACLK4CLK1CDK2CLK2 | |
| SCHEMBL25860940 | 0.77 | KDM1A (0.58) | DYRK1ACLK4CDK2CLK2SYK | |
| SCHEMBL28727095 | 0.75 | DYRK1A (0.56) | DYRK1ACLK4CLK1CDK2CLK2 | |
| SCHEMBL29481866 | 0.75 | DYRK1A (0.56) | DYRK1ACLK4CLK1CDK2CLK2 | |
| SCHEMBL28201498 | 0.75 | DYRK1A (0.56) | DYRK1ACLK4CLK1CDK2CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107721991-B | A kind of 6- (pyrimidine-4-yl) -1H- indazole derivative and its preparation method and application | 南方医科大学中西医结合医院 | 2019-10-18 | — | — | CN | disclosed |
| CN-107721991-A | A kind of 6 (base of pyrimidine 4) 1H indazole derivatives and its preparation method and application | 南方医科大学中西医结合医院 | 2018-02-23 | — | — | CN | disclosed |