SCHEMBL28205017

SCHEMBL28205017

NC(CC(=O)O)c1ccc(Br)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
KIF11 P52732 1/20 0.38
FFAR1 O14842 2/20 0.37
CYP2C9 P11712 3/20 0.36
MEN1 O00255 2/20 0.36
CYP2D6 P10635 2/20 0.36
CYP2C19 P33261 2/20 0.36
GABBR2 O75899 4/20 0.35
GABBR1 Q9UBS5 4/20 0.35
LMNA P02545 2/20 0.35
CYP3A4 P08684 1/20 0.35
ADORA3 P0DMS8 1/20 0.35
NFKB1 P19838 1/20 0.35
DRD3 P35462 1/20 0.35
BLM P54132 1/20 0.35
CYP1A2 P05177 1/20 0.35
THRB P10828 1/20 0.35
TSHR P16473 1/20 0.35
DPP4 P27487 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7951522 0.85 KMT2A (0.46) KMT2ASMN1; SMN2FFAR1CYP2C9MEN1
SCHEMBL17841359 0.85 KMT2A (0.46) KMT2ASMN1; SMN2FFAR1CYP2C9MEN1
SCHEMBL14580262 0.85 KMT2A (0.46) KMT2ASMN1; SMN2CYP2C9MEN1CYP2D6
SCHEMBL17857504 0.85 KMT2A (0.46) KMT2ASMN1; SMN2FFAR1CYP2C9MEN1
SCHEMBL30722300 0.84 KIF11 (0.36) KIF11FFAR1CYP1A2DPP4SLC6A4
Hydrochloric Acid SCHEMBL12497510 0.83 KMT2A (0.44) KMT2ASMN1; SMN2FFAR1CYP2C9MEN1
SCHEMBL14580270 0.81 AKR1C3 (0.47) KMT2ASMN1; SMN2FFAR1MEN1LMNA
SCHEMBL31601376 0.81 FFAR1 (0.46) KMT2AFFAR1CYP2C9MEN1CYP2C19
SCHEMBL3611759 0.80 ADRB2 (0.40) KIF11CYP1A2DPP4
SCHEMBL3611762 0.80 ADRB2 (0.40) KIF11CYP1A2DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107835818-A Anthelmintic depsipeptide compounds 梅里亚股份有限公司 2018-03-23 CN disclosed