Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.50 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.50 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 4/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KDM5C | P41229 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28100381 | 1.00 | EGLN1 (0.50) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Adipic Acid SCHEMBL10781777 | 0.90 | LMNA (0.55) | LMNATSHROR51E2SLC22A6NFKB1 | |
| Adipic Acid SCHEMBL1271948 | 0.90 | LMNA (0.55) | LMNATSHROR51E2SLC22A6NFKB1 | |
| Crotonic Acid SCHEMBL560763 | 0.85 | TSHR (0.57) | EGLN1LMNATSHRTP53EGLN3 | |
| Crotonic Acid SCHEMBL22034 | 0.85 | — | — | |
| Crotonic Acid SCHEMBL28429 | 0.85 | — | — | |
| Crotonic Acid SCHEMBL1428157 | 0.85 | TSHR (0.57) | EGLN1LMNATSHRTP53EGLN3 | |
| Crotonic Acid SCHEMBL1080122 | 0.85 | TSHR (0.57) | EGLN1LMNATSHRTP53EGLN3 | |
| Crotonic Acid SCHEMBL22033 | 0.85 | — | — | |
| Crotonic Acid SCHEMBL167626 | 0.85 | TSHR (0.57) | EGLN1LMNATSHRTP53EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107075068-B | Curable film-forming compositions and the method for reducing the dirt accumulation on substrate | PPG工业俄亥俄公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-109863209-A | Containing hydroxyl-functional, the acrylic polymer of branching curable film-forming composition and multi-layer composite coatings | PPG工业俄亥俄公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-109705716-A | The method for reducing ice accumulation on substrate | PPG工业俄亥俄公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-106536608-B | Acrylic polymer, curable film-forming composition prepared therefrom and the method for mitigating the dirt gathered on substrate | PPG工业俄亥俄公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-109642113-A | Show wet-edge time increased curable film-forming composition | PRC-迪索托国际公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-109581810-A | The method of photoetching compositions and manufacturing semiconductor devices for deep ultraviolet light | 三星电子株式会社 | 2019-04-05 | — | — | CN | disclosed |
| CN-109563357-A | Water-based composition and the compact process that multi-component composite coatings composition is formed on substrate | PPG工业俄亥俄公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-104345550-B | Colored photosensitive resin composition, colour filter and the liquid crystal display device with the colour filter | 东友精细化工有限公司 | 2019-03-19 | — | — | CN | disclosed |
| CN-106232746-B | Method for reducing ice build-up on a substrate | PPG工业俄亥俄公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-109031888-A | Colored photosensitive resin composition and light shield spacer prepared therefrom | 罗门哈斯电子材料韩国有限公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-108541258-A | The curable film-forming compositions of catalytic component containing encapsulating | PPG工业俄亥俄公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-108350131-A | Coated substrates prepared with aqueous sealer and primer compositions | PPG工业俄亥俄公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-103091986-B | Positive-type photosensitive resin composition, cured film and forming method thereof, liquid crystal display device and organic electroluminescence display device and method of manufacturing same | 富士胶片株式会社 | 2018-05-18 | — | — | CN | disclosed |
| CN-106103614-B | Use the painting method of the aqueous curable film-forming composition containing the polymer derived from gas material | PPG工业俄亥俄公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-104755563-B | Show the energy film-forming composition of resistance to polishability and low-luster | PPG工业俄亥俄公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107709483-A | Curable film-forming composition containing lithium silicate as corrosion inhibitor and multilayer coated metal substrate | PRC-迪索托国际公司 | 2018-02-16 | — | — | CN | disclosed |
| CN-107674089-A | Carbazole derivates, the light trigger and Photocurable composition for including it | 东友精细化工有限公司 | 2018-02-09 | — | — | CN | disclosed |
| CN-107592875-A | The curable film-forming composition of the thermoactive material containing light, the metal base of coating and the method for coating base material | PPG工业俄亥俄公司 | 2018-01-16 | — | — | CN | disclosed |
| CN-107075068-A | Curable film-forming compositions and the method for reducing the dirt accumulation on base material | PPG工业俄亥俄公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-106103614-A | Use the painting method of the aqueous curable film-forming composition containing the polymer derived from gas material | PPG工业俄亥俄公司 | 2016-11-09 | — | — | CN | disclosed |