Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | GHSR | Q92847 | 4/20 | 0.53 |
| ▸ | MC4R | P32245 | 2/20 | 0.49 |
| ▸ | MC5R | P33032 | 1/20 | 0.49 |
| ▸ | MC3R | P41968 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL27709285 | 0.97 | KDM4E (0.57) | KDM4EMEN1MAPTTSHRKMT2A | |
| Dl-Tryptophan SCHEMBL28366886 | 0.97 | KDM4E (0.57) | KDM4EMEN1MAPTTSHRKMT2A | |
| Tryptophan SCHEMBL27641188 | 0.97 | KDM4E (0.57) | KDM4EMEN1MAPTTSHRKMT2A | |
| Dl-Tryptophan SCHEMBL28250969 | 0.94 | KDM4E (0.54) | KDM4EMEN1MAPTTSHRKMT2A | |
| Dl-Tryptophan SCHEMBL27093065 | 0.93 | KDM4E (0.61) | KDM4EMEN1MAPTTSHRKMT2A | |
| Tryptophan SCHEMBL27671666 | 0.93 | KDM4E (0.61) | KDM4EMEN1MAPTTSHRKMT2A | |
| Dl-Tryptophan SCHEMBL28466764 | 0.93 | KDM4E (0.61) | KDM4EMEN1MAPTTSHRKMT2A | |
| Dl-Tryptophan SCHEMBL22587382 | 0.93 | KDM4E (0.61) | KDM4EMEN1MAPTTSHRKMT2A | |
| Dl-Tryptophan SCHEMBL27660745 | 0.92 | KMT2A (0.63) | KDM4EMEN1MAPTTSHRKMT2A | |
| Dl-Tryptophan SCHEMBL28861116 | 0.91 | KMT2A (0.58) | KDM4EMEN1MAPTTSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107759664-A | A kind of micromolecule polypeptide AKK10 and its application | 中国科学院新疆理化技术研究所 | 2018-03-06 | — | — | CN | disclosed |