Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132547 | 0.79 | RAB9A (0.61) | MAPTALOX15SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL1853364 | 0.79 | LMNA (0.56) | IDO1MAPTALOX15SMN1; SMN2NFKB1 | |
| SCHEMBL7125769 | 0.79 | IDO1 (0.49) | IDO1MAPTALOX15SMN1; SMN2NFKB1 | |
| SCHEMBL2870717 | 0.76 | IDO1 (0.46) | IDO1MAPTALOX15SMN1; SMN2NFKB1 | |
| SCHEMBL15425113 | 0.76 | MAPT (0.62) | IDO1MAPTALOX15SMN1; SMN2NFKB1 | |
| SCHEMBL22815484 | 0.75 | IDO1 (0.45) | IDO1MAPTALOX15SMN1; SMN2NFKB1 | |
| SCHEMBL22327927 | 0.75 | MAPT (0.47) | IDO1MAPTALOX15SMN1; SMN2NFKB1 | |
| SCHEMBL8888496 | 0.74 | RAB9A (0.70) | IDO1MAPTALOX15SMN1; SMN2NFKB1 | |
| SCHEMBL70801 | 0.73 | HCAR2 (0.56) | IDO1MAPTALOX15SMN1; SMN2NFKB1 | |
| SCHEMBL15425109 | 0.73 | KDM4E (0.55) | MAPTALOX15SMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108017641-B | Pyrazolopyrimidine compound as PI3K inhibitor and application thereof | 深圳铂立健医药有限公司 | 2021-01-05 | — | — | CN | disclosed |
| CN-108017641-A | Pyrazolopyrimidine compound is as PI3K inhibitor and its application | 叶宝欢 | 2018-05-11 | — | — | CN | disclosed |