Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | CASP6 | P55212 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 1/20 | 0.36 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17954911 | 0.86 | HPGD (0.41) | HPGDNOTUMKMT2AMEN1CHRM1 | |
| SCHEMBL11032644 | 0.83 | HPGD (0.59) | HPGDNOTUMKMT2AMEN1CASP6 | |
| SCHEMBL30886769 | 0.80 | KMT2A (0.44) | HPGDNOTUMKMT2AMEN1CASP6 | |
| SCHEMBL29256925 | 0.80 | KMT2A (0.44) | HPGDNOTUMKMT2AMEN1CASP6 | |
| SCHEMBL7008036 | 0.80 | HPGD (0.62) | HPGDNOTUMKMT2AMEN1CASP6 | |
| SCHEMBL6036422 | 0.77 | SRD5A1 (0.37) | HPGDKMT2AMEN1CASP6GAA | |
| SCHEMBL30874670 | 0.76 | MAPT (0.42) | HPGDNOTUMKMT2AMEN1GAA | |
| SCHEMBL2982634 | 0.73 | GAA (0.59) | HPGDNOTUMKMT2AMEN1CASP6 | |
| SCHEMBL6765903 | 0.73 | HPGD (0.74) | HPGDNOTUMKMT2AMEN1CASP6 | |
| SCHEMBL29651988 | 0.73 | GAA (0.59) | HPGDNOTUMKMT2AMEN1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109503399-B | Preparation method of Robenxib | 江苏天和制药有限公司 | 2021-12-24 | — | — | CN | claimed |
| CN-109503399-A | A kind of preparation method of rofecoxib | 江苏天和制药有限公司 | 2019-03-22 | — | — | CN | claimed |
| CN-107721901-A | A kind of preparation method of 2 [2 (2,3,5,6 phenyl tetrafluoride amido) phenyl] acetic acid | 刘磊 | 2018-02-23 | — | — | CN | claimed |
| CN-117886710-A | Synthesis method of roxburgh Bei Kao shake | 武汉回盛生物科技股份有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-109503399-B | Preparation method of Robenxib | 江苏天和制药有限公司 | 2021-12-24 | — | — | CN | disclosed |
| CN-109503399-B | Preparation method of Robenxib | 江苏天和制药有限公司 | 2021-12-24 | — | — | CN | disclosed |
| CN-109503399-A | A kind of preparation method of rofecoxib | 江苏天和制药有限公司 | 2019-03-22 | — | — | CN | disclosed |
| CN-107721901-A | A kind of preparation method of 2 [2 (2,3,5,6 phenyl tetrafluoride amido) phenyl] acetic acid | 刘磊 | 2018-02-23 | — | — | CN | disclosed |