Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 7/20 | 0.55 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.55 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69802 | 0.78 | SCN4A (0.45) | ALDH1A1CYP3A4HSD17B10KDM4EMAPT | |
| SCHEMBL4044619 | 0.77 | MKNK1 (0.41) | CYP3A4CYP19A1IDO1 | |
| SCHEMBL5092536 | 0.76 | PDPK1 (0.48) | LMNATP53MAPTNISCHNPY5R | |
| SCHEMBL6381205 | 0.73 | CYP2A6 (0.54) | CYP2A6CYP2E1CYP2B6ALDH1A1CYP3A4 | |
| SCHEMBL4047215 | 0.73 | CYP1A2 (0.40) | ALDH1A1CYP3A4CYP1A2HSD17B10KDM4E | |
| SCHEMBL29597274 | 0.71 | CYP2A6 (1.00) | CYP2A6CYP2E1CYP2B6ALDH1A1CYP3A4 | |
| SCHEMBL13425468 | 0.71 | CYP2A6 (1.00) | CYP2A6CYP2E1CYP2B6ALDH1A1CYP3A4 | |
| SCHEMBL30473120 | 0.70 | CYP2A6 (1.00) | CYP2A6CYP2E1CYP2B6ALDH1A1CYP3A4 | |
| SCHEMBL29419014 | 0.70 | CYP2A6 (1.00) | CYP2A6CYP2E1CYP2B6ALDH1A1CYP3A4 | |
| SCHEMBL120088 | 0.70 | CYP2A6 (1.00) | CYP2A6CYP2E1CYP2B6ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010075356-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-07-01 | — | — | WO | disclosed |
| US-20100160323-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-06-24 | — | — | US | disclosed |
| US-7393873-B2 | Arylsulfonamide derivatives | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-20060142612-A1 | Arylsulfonamide derivatives | MERCK SHARP & DOHME CORP. | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160323-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | SCD, SCD5, FADS2 | CYP2A6 1654/4885CYP2E1 1363/4885CYP2B6 2144/4885 |
| US-20060142612-A1 | Arylsulfonamide derivatives | BDKRB1, BDKRB2, LTB4R2 | CYP2A6 759/4885CYP2E1 815/4885CYP2B6 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.