Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.47 |
| ▸ | HNF4A | P41235 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29499766 | 0.92 | TSHR (0.65) | TSHRALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL372307 | 0.92 | TSHR (0.65) | TSHRALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL431965 | 0.90 | TSHR (0.63) | TSHRALDH1A1KDM4EHSD17B10KMT2A | |
| Ammonia Solution, Strong SCHEMBL28934927 | 0.90 | TSHR (0.63) | TSHRALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL425111 | 0.90 | TSHR (0.63) | TSHRALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL10779360 | 0.90 | TSHR (0.63) | TSHRALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL10779351 | 0.90 | TSHR (0.63) | TSHRALDH1A1KDM4EHSD17B10KMT2A | |
| Potassium Ion SCHEMBL28934908 | 0.84 | ALDH1A1 (0.47) | TSHRALDH1A1KDM4EHSD17B10KMT2A | |
| Salicylic Acid SCHEMBL28162812 | 0.83 | ALDH1A1 (0.67) | TSHRALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL10779354 | 0.80 | ALDH1A1 (0.52) | TSHRALDH1A1KDM4EHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105801397-B | A kind of continuous production technology of 3,6- dichlorosalicylic acids | 四川福思达生物技术开发有限责任公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-105801378-B | A kind of preparation method of 3,6 dichlorosalicylic acid | 四川福思达生物技术开发有限责任公司 | 2018-04-13 | — | — | CN | disclosed |