Niacinamide

Niacinamide

SCHEMBL28209434

COC(=O)OC.NC(=O)c1cccnc1

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F7 P08709 1/20 0.76
F3 P13726 1/20 0.76
SARM1 Q6SZW1 1/20 0.76
SIRT2 Q8IXJ6 1/20 0.76
SIRT6 Q8N6T7 1/20 0.76
SIRT1 Q96EB6 1/20 0.76
SIRT3 Q9NTG7 1/20 0.76
SIRT5 Q9NXA8 1/20 0.76
SIRT4 Q9Y6E7 1/20 0.76
ALDH1A1 P00352 3/20 0.64
KMT2A Q03164 4/20 0.54
MEN1 O00255 1/20 0.54
APP P05067 1/20 0.52
GAA P10253 1/20 0.52
HCAR3 P49019 1/20 0.52
HCAR2 Q8TDS4 1/20 0.52
MKNK1 Q9BUB5 2/20 0.51
MKNK2 Q9HBH9 2/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC6 Q9UBN7 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Niacinamide SCHEMBL28248195 0.89 F7 (0.81) F7F3SARM1SIRT2SIRT6
Methyl Nicotinate SCHEMBL28657691 0.88 ALDH1A1 (0.83) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL5712652 0.87 F7 (0.92) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL27671762 0.87 F7 (0.92) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL29624874 0.87
Niacinamide SCHEMBL19978192 0.87
Niacinamide SCHEMBL460466 0.87 F7 (1.00) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL2926 0.87
Niacinamide SCHEMBL28744959 0.85 F7 (0.88) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL20298468 0.85 F7 (0.88) F7F3SARM1SIRT2SIRT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107920988-A For extending the liquid polymers delivery system of administration 托尔玛国际有限公司 2018-04-17 CN disclosed