Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | USP1 | O94782 | 1/20 | 0.40 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28210685 | 0.85 | NR4A2 (0.44) | KCNA5CYP2A6NR4A2PDCD1CD274 | |
| SCHEMBL477395 | 0.82 | KCNA5 (0.61) | MKNK1MKNK2KCNA5GAACYP11B1 | |
| SCHEMBL30790364 | 0.82 | PDCD1 (0.60) | ALDH1A1NR4A2PDCD1CD274PDK2 | |
| SCHEMBL9548114 | 0.82 | PDCD1 (0.60) | ALDH1A1NR4A2PDCD1CD274PDK2 | |
| SCHEMBL30091380 | 0.80 | PDCD1 (0.69) | MKNK1MKNK2KCNA5GAACYP11B1 | |
| SCHEMBL11074941 | 0.80 | PDCD1 (0.69) | MKNK1MKNK2KCNA5GAACYP11B1 | |
| SCHEMBL10966421 | 0.79 | KCNA5 (0.54) | MKNK1MKNK2KCNA5GAACYP11B1 | |
| SCHEMBL19923153 | 0.78 | PDCD1 (0.47) | NR4A2PDCD1CD274PDK2 | |
| SCHEMBL28997762 | 0.77 | CYP11B1 (0.55) | MKNK1MKNK2CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL5144683 | 0.77 | CYP2A6 (0.58) | MKNK1MKNK2KCNA5GAACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922379-A | Substituted guanidine derivatives | 宇部兴产株式会社 | 2018-04-17 | — | — | CN | disclosed |