Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18468495 | 0.86 | SLC18A3 (0.57) | DRD2SLC18A3KDM1ADRD3DRD1 | |
| SCHEMBL21148130 | 0.86 | SLC18A3 (0.57) | DRD2SLC18A3KDM1ADRD3DRD1 | |
| SCHEMBL14544193 | 0.84 | DRD2 (0.47) | HRH3DRD2SLC18A3KDM1ADRD3 | |
| SCHEMBL22415999 | 0.83 | DRD2 (0.60) | MAPK11MAPK14DRD2DRD3DRD1 | |
| SCHEMBL22415828 | 0.83 | DRD2 (0.50) | DRD2SLC18A3DRD3DRD1DRD5 | |
| SCHEMBL14321119 | 0.83 | DRD2 (0.46) | HRH1DRD2SLC18A3KDM1ADRD3 | |
| SCHEMBL30010274 | 0.83 | DRD2 (0.50) | DRD2SLC18A3DRD3DRD1DRD5 | |
| SCHEMBL24697925 | 0.80 | CCNT1 (0.45) | HRH1DRD2DRD3DRD1DRD4 | |
| SCHEMBL22415909 | 0.80 | CCNT1 (0.39) | MAPK11MAPK14 | |
| SCHEMBL30010674 | 0.80 | CCNT1 (0.39) | MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108329246-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compound as TRKA kinase inhibitors | 阵列生物制药公司 | 2018-07-27 | — | — | CN | disclosed |
| CN-105130967-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compound as TRKA kinase inhibitors | 阵列生物制药公司 | 2018-04-17 | — | — | CN | disclosed |