Known targets — ChEMBL curated mechanism
S1PR1S1PR2S1PR3S1PR4S1PR5rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 16/20 | 0.63 |
| ▸ | CA2 | P00918 | 16/20 | 0.63 |
| ▸ | CA9 | Q16790 | 14/20 | 0.63 |
| ▸ | CA12 | O43570 | 5/20 | 0.63 |
| ▸ | CA7 | P43166 | 5/20 | 0.63 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.63 |
| ▸ | CA3 | P07451 | 4/20 | 0.63 |
| ▸ | CA4 | P22748 | 4/20 | 0.63 |
| ▸ | CA6 | P23280 | 4/20 | 0.63 |
| ▸ | CA5A | P35218 | 4/20 | 0.63 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.63 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octadecyl Sulfate SCHEMBL27728765 | 0.98 | CA1 (0.61) | CA1CA2CA9CA12CA7 | |
| Methylamine SCHEMBL6901577 | 0.96 | CA1 (0.63) | CA1CA2CA9CA12CA7 | |
| Methylamine SCHEMBL6903099 | 0.96 | CA1 (0.63) | CA1CA2CA9CA12CA7 | |
| Methylamine SCHEMBL6901043 | 0.96 | CA1 (0.63) | CA1CA2CA9CA12CA7 | |
| Octadecyl Sulfate SCHEMBL14676499 | 0.96 | CA1 (0.63) | CA1CA2CA9CA12CA7 | |
| Methylamine SCHEMBL14675584 | 0.96 | CA1 (0.63) | CA1CA2CA9CA12CA7 | |
| SCHEMBL9018754 | 0.96 | CA1 (0.61) | CA1CA2CA9CA12CA7 | |
| SCHEMBL144603 | 0.96 | CA1 (0.61) | CA1CA2CA9CA12CA7 | |
| SCHEMBL4904743 | 0.96 | CA1 (0.61) | CA1CA2CA9CA12CA7 | |
| SCHEMBL374800 | 0.96 | CA1 (0.61) | CA1CA2CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110505866-A | Composition of skin cleanser | KAO CORP | 2019-11-26 | — | — | CN | disclosed |
| CN-109715130-A | HAIR CARE COMPOSITIONS COMPRISING GLYCERIDE COPOLYMERS | 宝洁公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-109715133-A | The cosmetic material and oil-in-water emulsion type cosmetic preparation of core-shell type particle are used | 株式会社资生堂 | 2019-05-03 | — | — | CN | disclosed |
| CN-109562137-A | Methods and compositions for treating conditions associated with abnormal inflammatory responses | 第波生物公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109414599-A | Hair care composition comprising metathesized unsaturated polyol ester | 宝洁公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109205609-A | A kind of method that solution naturally dry prepares three-dimensional graphene oxide foamed material | 北京理工大学 | 2019-01-15 | — | — | CN | disclosed |
| CN-105585601-B | Anti-aging skin external composition and preparation method thereof | 株式会社林原 | 2018-11-13 | — | — | CN | disclosed |
| CN-108697609-A | Aerosol anti-dandruff compositions | 宝洁公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-108515656-A | Prepare the continuation method for dissolving the product to deliver surfactant when in use | 宝洁公司 | 2018-09-11 | — | — | CN | disclosed |
| CN-103221030-B | Intermediates and surfactants for household cleaning and personal care compositions, and methods for making the same | 宝洁公司 | 2018-05-29 | — | — | CN | disclosed |
| CN-108024531-A | The agriculture adjuvant composition and application method of oil/surfactant/salt lotion | 罗地亚经营管理公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-105050567-B | Include the personal care composition of pre-emulsified preparation | 宝洁公司 | 2018-04-27 | — | — | CN | disclosed |
| CN-107921007-A | Patch | 株式会社钟化 | 2018-04-17 | — | — | CN | disclosed |