Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 12/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088944 | 0.95 | CCR2 (0.48) | CCR2CCR1CCR5CXCR4RAB9A | |
| SCHEMBL27638680 | 0.95 | CCR2 (0.48) | CCR2CCR1CCR5CXCR4RAB9A | |
| SCHEMBL28500818 | 0.91 | CCR2 (0.38) | CCR2CCR1CCR5CXCR4 | |
| SCHEMBL11402075 | 0.79 | L3MBTL1 (0.43) | CCR2L3MBTL1ALDH1A1HSD17B10POLB | |
| SCHEMBL11402077 | 0.79 | L3MBTL1 (0.43) | CCR2L3MBTL1ALDH1A1HSD17B10POLB | |
| SCHEMBL29190149 | 0.76 | KDM4E (0.42) | ALDH1A1HSD17B10POLBMEN1KMT2A | |
| SCHEMBL28112273 | 0.76 | KDM4E (0.42) | ALDH1A1HSD17B10POLBMEN1KMT2A | |
| SCHEMBL28982949 | 0.76 | KDM4E (0.42) | ALDH1A1HSD17B10POLBMEN1KMT2A | |
| SCHEMBL4773108 | 0.76 | DDB1 (0.46) | — | |
| SCHEMBL17817926 | 0.75 | L3MBTL1 (0.43) | CCR2L3MBTL1ALDH1A1HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104428299-B | 5- azaindazole compounds and its application method | 霍夫曼-拉罗奇有限公司 | 2018-05-11 | — | — | CN | disclosed |