Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CPA1 | P15085 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL28304623 | 0.94 | TDP1 (0.59) | TDP1TSHRALDH1A1MEN1KMT2A | |
| Propylene Glycol SCHEMBL27821323 | 0.94 | TDP1 (0.59) | TDP1TSHRALDH1A1MEN1KMT2A | |
| Propylene Glycol SCHEMBL28216317 | 0.94 | TDP1 (0.59) | TDP1TSHRALDH1A1MEN1KMT2A | |
| Propylene Glycol SCHEMBL44181 | 0.88 | TDP1 (0.59) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL7262024 | 0.88 | TDP1 (0.59) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL259009 | 0.88 | TDP1 (0.59) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL962369 | 0.88 | — | — | |
| Propylene Glycol SCHEMBL28260299 | 0.86 | — | — | |
| Propylene Glycol SCHEMBL28430579 | 0.79 | TDP1 (0.48) | TDP1TSHRMEN1KMT2ALMNA | |
| Glycerin SCHEMBL27618689 | 0.79 | LMNA (0.56) | TDP1ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130321-B | A kind of polymer cement waterproof paint that can be used under low temperature environment | 昆明风行防水材料有限公司 | 2018-05-29 | — | — | CN | claimed |