Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.59 |
| ▸ | RXRA | P19793 | 5/20 | 0.47 |
| ▸ | RXRB | P28702 | 5/20 | 0.47 |
| ▸ | RXRG | P48443 | 4/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4824826 | 0.86 | KIF11 (0.71) | KIF11RXRARXRBRXRGESR1 | |
| SCHEMBL21389063 | 0.80 | ESR1 (0.74) | KIF11ESR1ABL1ABCB1BCR | |
| SCHEMBL1513590 | 0.80 | ESR1 (0.65) | KIF11ESR1ABL1ABCB1BCR | |
| SCHEMBL26825137 | 0.78 | RXRA (0.55) | KIF11RXRARXRBRXRGS1PR1 | |
| SCHEMBL24038362 | 0.78 | RXRA (0.55) | KIF11RXRARXRBRXRGS1PR1 | |
| SCHEMBL13103965 | 0.78 | KIF11 (0.54) | KIF11RXRARXRBRXRGS1PR1 | |
| SCHEMBL27978615 | 0.78 | KIF11 (0.54) | KIF11RXRARXRBRXRGS1PR1 | |
| SCHEMBL16421654 | 0.78 | RXRA (0.44) | RXRARXRBRXRGS1PR1S1PR3 | |
| SCHEMBL1336153 | 0.76 | NOTUM (0.47) | KIF11S1PR1S1PR3NOTUM | |
| SCHEMBL29561341 | 0.76 | NOTUM (0.47) | KIF11S1PR1S1PR3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |