Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246399 | 0.93 | HTR3E (0.49) | GRM4HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1525499 | 0.90 | HTR3E (0.44) | GRM4HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL30019653 | 0.90 | HTR3E (0.44) | GRM4HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1513968 | 0.89 | NPFFR2 (0.43) | GRM4HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27734542 | 0.89 | HTR3E (0.43) | GRM4HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1513809 | 0.89 | HTR3E (0.43) | GRM4HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL58712 | 0.88 | GRM4 (0.46) | GRM4KDRLMNASMN1; SMN2USP2 | |
| SCHEMBL27514280 | 0.88 | TRPV1 (0.43) | GRM4HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL28217568 | 0.85 | GRM4 (0.43) | GRM4ALDH1A1NPSR1POLQ | |
| SCHEMBL27907319 | 0.83 | S1PR1 (0.39) | GRM4HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026035-A | Compounds having protein tyrosine phosphatase SHP-1 agonist activity | 陈昆锋 | 2018-05-11 | — | — | CN | disclosed |