Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | POLQ | O75417 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28217604 | 0.88 | GRM4 (0.44) | GRM4KDRLMNASMN1; SMN2USP2 | |
| SCHEMBL1942998 | 0.88 | POLQ (0.41) | KDRLMNASMN1; SMN2USP2ALDH1A1 | |
| SCHEMBL59388 | 0.84 | GRM4 (0.45) | GRM4ALDH1A1POLQNPSR1NOTUM | |
| SCHEMBL2091976 | 0.80 | NPSR1 (0.47) | LMNAALDH1A1TSHRPPARGNPSR1 | |
| SCHEMBL27564932 | 0.80 | MAPT (0.42) | KDRLMNAS1PR1MAPTNOTUM | |
| SCHEMBL4246399 | 0.80 | HTR3E (0.49) | GRM4KDRLMNASMN1; SMN2S1PR1 | |
| SCHEMBL1942322 | 0.78 | TAS2R14 (0.49) | — | |
| SCHEMBL30019653 | 0.78 | HTR3E (0.44) | GRM4KDRLMNAS1PR1TP53 | |
| SCHEMBL1525499 | 0.78 | HTR3E (0.44) | GRM4KDRLMNAS1PR1TP53 | |
| SCHEMBL1513968 | 0.77 | NPFFR2 (0.43) | GRM4KDRLMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783499-B2 | Quinoline derivatives and their applications | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2017-10-10 | — | — | US | disclosed |
| US-20150307453-A1 | NOVEL QUINOLINE DERIVATIVES AND THEIR APPLICATIONS | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2015-10-29 | — | — | US | disclosed |
| US-8338595-B2 | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-8143393-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-27 | — | — | US | disclosed |
| CN-102311384-A | Preparation method of sorafenib | XIANGZHEN BIOTECHNOLOGY CO LTD | 2012-01-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307453-A1 | NOVEL QUINOLINE DERIVATIVES AND THEIR APPLICATIONS | MET, RAF1, RET | GRM4 1518/4885KDR 297/4885LMNA 1971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.