Acarbose

SCHEMBL28219610

C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)O[C@@H]3CO)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@H](O)[C@H](O)[C@H]1O.OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](O)C(O)O[C@@H]3CO)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AMY2A MGAM

The experimentally established mechanism targets of Acarbose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	AMY2A known ✓	P04746	9/20	0.94

▸	MGAM known ✓	O43451	6/20	0.94

▸	SI	P14410	5/20	0.94

▸	GAA	P10253	4/20	0.94

▸	AMY1A	P0DUB6	3/20	0.94

▸	CNR1	P21554	1/20	0.94

▸	PTGS1	P23219	1/20	0.94

▸	PDE4A	P27815	1/20	0.94

▸	PDE3A	Q14432	1/20	0.94

▸	MGAM2	Q2M2H8	1/20	0.94

▸	ALDH1A1	P00352	1/20	0.94

▸	GLA	P06280	1/20	0.94

▸	TREH	O43280	1/20	0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acarbose SCHEMBL8798558	1.00	AMY2A (0.94)	AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL611277	0.97	AMY2A (1.00)	AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL14223718	0.97	AMY2A (1.00)	AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL19736300	0.97	AMY2A (1.00)	AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL22252576	0.97	AMY2A (1.00)	AMY2AMGAMSIGAAAMY1A
SCHEMBL14409049	0.97	AMY2A (1.00)	AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL4068725	0.97	AMY2A (1.00)	AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL9929862	0.97	AMY2A (1.00)	AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL22651301	0.97	AMY2A (1.00)	AMY2AMGAMSIGAAAMY1A
Acarbose SCHEMBL22252575	0.97	AMY2A (1.00)	AMY2AMGAMSIGAAAMY1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-108138167-A	The manufacturing method of linalool	味之素株式会社	2018-06-08	—	—	CN	disclosed
CN-108138168-A	Linalool composition and preparation method thereof	味之素株式会社	2018-06-08	—	—	CN	disclosed