Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acarbose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY2A known ✓ | P04746 | 9/20 | 1.00 |
| ▸ | MGAM known ✓ | O43451 | 6/20 | 1.00 |
| ▸ | SI | P14410 | 5/20 | 1.00 |
| ▸ | GAA | P10253 | 4/20 | 1.00 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | TREH | O43280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acarbose SCHEMBL19736300 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL681337 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL9929862 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL22252575 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL22252576 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| SCHEMBL14409049 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL4068725 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL14223718 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL22651301 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL16204157 | 1.00 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| EP-3062782-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | Pharnext (FR) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| EP-2914252-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | Pharnext (FR) | 2015-09-09 | — | — | EP | disclosed |
| WO-2015063140-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2015-05-07 | — | — | WO | disclosed |
| WO-2014068007-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2014-05-08 | — | — | WO | disclosed |
| US-20120040025-A9 | Compositions and Methods for Treating Disorders Associated with Salt or Fluid Retention | IRONWOOD PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
| US-20100215779-A1 | Compositions and Methods for Treating Disorders Associated with Salt or Fluid Retention | IRONWOOD PHARMACEUTICALS, INC. | 2010-08-26 | — | — | US | disclosed |
| US-20080096915-A1 | An oral formulation of cicletanine and ruboxistaurin; diabetes, diabetic complications, dyslipidemia, and metabolic disorders | Greenberg Traurig LLP (US) | 2008-04-24 | — | — | US | disclosed |
| US-20070141174-A1 | Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension | NAVITAS PHARMA, INC. (US) | 2007-06-21 | — | — | US | disclosed |
| US-20060089374-A1 | Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease | NAVITAS ASSETS, LLC | 2006-04-27 | — | — | US | disclosed |
| US-6387361-B1 | Use for drug acarbose precose for weight control prevention of weight gain for weight loss for treatment and prevention of obesity | ROSNER HARVEY (US) | 2002-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040025-A9 | Compositions and Methods for Treating Disorders Associated with Salt or Fluid Retention | SLC10A2, SLC10A1, SLC26A3 | AMY2A 156/4885MGAM 302/4885SI 14/4885 |
| US-20100215779-A1 | Compositions and Methods for Treating Disorders Associated with Salt or Fluid Retention | SLC10A2, SLC10A1, SLC26A3 | AMY2A 156/4885MGAM 302/4885SI 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.