Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27683363 | 0.87 | NOS3 (0.41) | NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL27671529 | 0.85 | NOS3 (0.40) | NOS3NOS1NOS2 | |
| SCHEMBL27875671 | 0.79 | NOS3 (0.36) | NOS3NOS1NOS2 | |
| Creatine SCHEMBL29400407 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2NOS3NOS1NOS2TET2 | |
| Creatine SCHEMBL623785 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2NOS3NOS1NOS2TET2 | |
| Creatine SCHEMBL29404550 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2NOS3NOS1NOS2TET2 | |
| Malic Acid SCHEMBL8928445 | 0.75 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1 | |
| Malic Acid SCHEMBL5874761 | 0.73 | SMN1; SMN2 (0.79) | SMN1; SMN2TET2TET3TET1 | |
| Malic Acid SCHEMBL5874756 | 0.73 | SMN1; SMN2 (0.79) | SMN1; SMN2TET2TET3TET1 | |
| Malic Acid SCHEMBL19878636 | 0.71 | SMN1; SMN2 (0.56) | SMN1; SMN2TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108102813-A | A kind of children wash one's hands cleaning material | 孝感市锐思新材科技有限公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-108102813-A | A kind of children wash one's hands cleaning material | 孝感市锐思新材科技有限公司 | 2018-06-01 | — | — | CN | disclosed |