Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Creatine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.33 |
| ▸ | TET3 | O43151 | 2/20 | 0.33 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 5/20 | 0.33 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.31 |
| ▸ | KDM4A | O75164 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Creatine SCHEMBL29400407 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2NOS3NOS1NOS2TET2 | |
| Creatine SCHEMBL29404550 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2NOS3NOS1NOS2TET2 | |
| Cadaverine Tartrate SCHEMBL1286961 | 0.85 | NOS3 (0.47) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL4281967 | 0.84 | NOS3 (0.40) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL1883324 | 0.84 | NOS3 (0.46) | NOS3NOS1NOS2CA1CA2 | |
| Malic Acid SCHEMBL31238937 | 0.84 | CA12 (0.43) | SMN1; SMN2NOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL31156412 | 0.83 | NOS3 (0.44) | NOS3NOS1NOS2CA1CA2 | |
| Creatine SCHEMBL30063981 | 0.83 | — | — | |
| Creatine SCHEMBL21567 | 0.83 | — | — | |
| Creatine SCHEMBL27979093 | 0.83 | NOS3 (0.46) | NOS3NOS1NOS2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 290 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240138438-A1 | CREATINE NUTRITIONAL SUPPLEMENT | MENTER DYLAN (US) | 2024-05-02 | — | — | US | claimed |
| US-11865097-B2 | Creatine nutritional supplement | MENTER DYLAN (US) | 2024-01-09 | — | — | US | claimed |
| US-20230233499-A1 | CREATINE NUTRITIONAL SUPPLEMENT | MENTER DYLAN (US) | 2023-07-27 | — | — | US | claimed |
| US-11690858-B1 | Neuroprotective mixture for mitigating the harmful effects of ischemic stroke | TRICERAPRO HOLDING, LLC (US) | 2023-07-04 | — | — | US | claimed |
| US-11642327-B2 | Creatine nutritional supplement | MENTER DYLAN ROBERT (US) | 2023-05-09 | — | — | US | claimed |
| US-20230108723-A1 | Multi-Nutrient Composition | EXERKINE CORPORATION (CA) | 2023-04-06 | — | — | US | claimed |
| US-11504413-B2 | Multi-nutrient composition | EXERKINE CORPORATION (CA) | 2022-11-22 | — | — | US | claimed |
| US-20220287346-A1 | STABLE CREATINE BEVERAGES | THE COCA-COLA COMPANY | 2022-09-15 | — | — | US | claimed |
| EP-4017282-A1 | STABLE CREATINE BEVERAGES | The Coca-Cola Company (US) | 2022-06-29 | — | — | EP | claimed |
| US-20220054442-A1 | Creatine Nutritional Supplement | MENTER DYLAN (US) | 2022-02-24 | — | — | US | claimed |
| EP-1744732-A2 | NUTRITIONAL COMPOSITION FOR INCREASING CREATINE UPTAKE IN SKELETAL MUSCLE | Thermo Formulations Ltd. (CA) | 2007-01-24 | — | — | EP | claimed |
| US-20060280814-A1 | Nutritional composition for increasing creatine uptake in skeletal muscle | GARDINER PAUL T | 2006-12-14 | — | — | US | claimed |
| WO-2005110448-A2 | NUTRITIONAL COMPOSITION FOR INCREASING CREATINE UPTAKE IN SKELETAL MUSCLE | THERMO FORMULATIONS LTD. (CA) | 2005-11-24 | — | — | WO | claimed |
| WO-2005107735-A2 | NUTRITIONAL COMPOSITION FOR ENHANCING LEAN MUSCLE STIMULUS, GROWTH, STRENGTH AND RECOVERY, CREATING AND PROLONGING INTENSE MUSCLE PUMPS, SUPPORTING ENDURANCE, STRENGTH, PERFORMANCE, SIZE AND STAMINA, PROVIDING A TRANSDUCER EFFECT FOR NITRIC OXIDE, INCRESING NUTRIENT DELIVERY AND/OR PROMOTING INCREASED VASCULAR RESPONSE IN A | PUMP FORMULATIONS, LTD. (CA) | 2005-11-17 | — | — | WO | claimed |
| CN-1224328-C | Use of creatine as fodder additive | DSM FINE CHEM AUSTRIA GMBH (AT) | 2005-10-26 | — | — | CN | claimed |
| EP-1176875-B1 | USE OF CREATINE AS A FEED SUBSTITUTE | DSM FINE CHEM AUSTRIA GMBH (AT) | 2005-01-19 | — | — | EP | claimed |
| US-20040228884-A1 | Ion-pair delivery system for cosmetic and pharmaceutical compositions | GUPTA SHYAM K (US) | 2004-11-18 | — | — | US | claimed |
| US-20040156873-A1 | Topically Bioavailable Acne and Rosacea Treatment Compositions | GUPTA SHYAM K (US) | 2004-08-12 | — | — | US | claimed |
| US-20040092482-A1 | Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions | GUPTA SHYAM K (US) | 2004-05-13 | — | — | US | claimed |
| CN-1350434-A | Use of creatine as fodder additive | DSM FINE CHEMICALS AUSTRIA (AT) | 2002-05-22 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092482-A1 | Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions | CUTA, HIRA, HARS1 | SMN1; SMN2 4162/4885NOS3 2825/4885NOS1 2319/4885 |
| US-20060280814-A1 | Nutritional composition for increasing creatine uptake in skeletal muscle | CPT1B, CKMT1A; CKMT1B, MTPN | SMN1; SMN2 354/4885NOS3 922/4885NOS1 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.