Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.59 |
| ▸ | TNF | P01375 | 2/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 6/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.53 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15614056 | 0.77 | FADS1 (0.71) | MAPKAPK2RIPK2GAKCOQ8ANLK | |
| SCHEMBL5569117 | 0.74 | HTT (0.61) | TNFKDM4EMEN1LMNAMAPT | |
| SCHEMBL27175349 | 0.74 | TNF (0.48) | MAPKAPK2TNFRIPK2KDRHTR1A | |
| SCHEMBL827782 | 0.73 | NR4A2 (0.61) | MAPKAPK2RIPK2GAKCOQ8ANLK | |
| SCHEMBL21121619 | 0.73 | POLB (0.67) | RIPK2GAKKDM4EMEN1LMNA | |
| SCHEMBL2477414 | 0.72 | NR4A2 (0.61) | MAPKAPK2RIPK2GAKCOQ8ANLK | |
| Hydrochloric Acid SCHEMBL22029285 | 0.72 | POLB (0.65) | RIPK2GAKKDM4EMEN1LMNA | |
| SCHEMBL19160656 | 0.72 | CCNC (0.77) | MAPKAPK2KDM4EMEN1LMNAMAPT | |
| SCHEMBL7511001 | 0.72 | HTR1A (0.65) | MAPKAPK2KDM4ELMNAHTR1AADRA1D | |
| SCHEMBL4904427 | 0.72 | CYP1A2 (0.65) | MAPKAPK2GAKKDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137547-A | It can be used as the heterocyclic compound of TNF α conditioning agent | 百时美施贵宝公司 | 2018-06-08 | — | — | CN | disclosed |