Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28218711 | 0.85 | ALDH1A1 (0.41) | POLBGAAKMT2AMPOMAPT | |
| SCHEMBL2170302 | 0.81 | POLB (0.47) | POLBNR4A2KMT2AMPOMAPT | |
| SCHEMBL8127677 | 0.81 | POLB (0.47) | POLBNR4A2GAAKMT2AMPO | |
| SCHEMBL31252837 | 0.81 | POLB (0.47) | POLBNR4A2KMT2AMPOMAPT | |
| SCHEMBL4744795 | 0.78 | POLB (0.68) | POLBNR4A2KMT2AMPOMAPT | |
| SCHEMBL11343722 | 0.78 | NR4A2 (0.50) | POLBNR4A2KMT2AMPOMAPT | |
| SCHEMBL16097168 | 0.77 | MCL1 (0.46) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL28816057 | 0.75 | POLB (0.42) | POLBNR4A2KMT2AMPOMAPT | |
| SCHEMBL28807199 | 0.75 | MYC (0.48) | POLBGAAKMT2AKDM4EMEN1 | |
| 7-Chlorokynurenic Acid SCHEMBL31238955 | 0.74 | IGFBP3 (0.47) | POLBKMT2AHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137547-A | It can be used as the heterocyclic compound of TNF α conditioning agent | 百时美施贵宝公司 | 2018-06-08 | — | — | CN | disclosed |