Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | TP53 | P04637 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27383780 | 0.86 | MAPT (0.68) | MAPTTP53POLBLMNARXFP1 | |
| SCHEMBL20995404 | 0.83 | EGLN1 (0.69) | MAPTTP53POLBLMNARXFP1 | |
| SCHEMBL27383531 | 0.83 | MAPT (0.61) | MAPTTP53POLBLMNARXFP1 | |
| SCHEMBL28223469 | 0.82 | MAPT (0.52) | MAPTTP53POLBLMNAALDH1A1 | |
| SCHEMBL27383530 | 0.81 | MAPT (0.65) | MAPTTP53POLBLMNARXFP1 | |
| SCHEMBL15804049 | 0.80 | BRD4 (0.54) | MAPTPOLBLMNARXFP1ALDH1A1 | |
| SCHEMBL17477640 | 0.80 | MAPT (0.63) | MAPTTP53POLBLMNARXFP1 | |
| SCHEMBL27383551 | 0.79 | MAPT (0.56) | MAPTTP53POLBLMNARXFP1 | |
| SCHEMBL14611520 | 0.78 | MAPT (0.57) | MAPTTP53POLBLMNAALDH1A1 | |
| SCHEMBL30647255 | 0.76 | BRD4 (0.74) | MAPTTP53LMNARXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137542-A | Pyridone diformamide as bromine structural domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2018-06-08 | — | — | CN | disclosed |