SCHEMBL282266

SCHEMBL282266

CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2OC)ncc1Br

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ULK1 O75385 4/20 0.84
ALK Q9UM73 7/20 0.73
IGF1R P08069 5/20 0.73
EGFR P00533 4/20 0.73
PLK4 O00444 2/20 0.73
CHEK1 O14757 2/20 0.73
AURKA O14965 2/20 0.73
DCLK1 O15075 2/20 0.73
PDPK1 O15530 2/20 0.73
DAPK3 O43293 2/20 0.73
JAK2 O60674 2/20 0.73
ROCK2 O75116 2/20 0.73
PRKD3 O94806 2/20 0.73
MAP4K4 O95819 2/20 0.73
PAK4 O96013 2/20 0.73
CHEK2 O96017 2/20 0.73
ERBB2 P04626 2/20 0.73
NTRK1 P04629 2/20 0.73
LCK P06239 2/20 0.73
FYN P06241 2/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1911991 0.92 ULK1 (0.72) ULK1ALKIGF1REGFRPLK4
SCHEMBL12892789 0.92 ULK1 (0.71) ULK1ALKIGF1REGFRPLK4
SCHEMBL375608 0.91 ULK1 (1.00) ULK1ALKIGF1REGFRPLK4
SCHEMBL29900883 0.91 ULK1 (1.00) ULK1ALKIGF1REGFRPLK4
SCHEMBL30123962 0.91 EGFR (0.77) ULK1ALKIGF1REGFRPLK4
SCHEMBL26451583 0.91 EGFR (0.77) ULK1ALKIGF1REGFRPLK4
SCHEMBL13394913 0.90 ALK (0.74) ULK1ALKIGF1REGFRPLK4
SCHEMBL4094604 0.88 ALK (0.72) ULK1ALKIGF1REGFRPLK4
SCHEMBL12781002 0.88 ULK1 (0.77) ULK1ALKIGF1REGFRPLK4
SCHEMBL12892811 0.87 ULK1 (0.67) ULK1ALKIGF1REGFRPLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150184161-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2015-07-02 US claimed
EP-2116553-B1 EML4-ALK fusion gene ASTELLAS PHARMA INC (JP) 2014-07-30 EP claimed
US-20130158095-A1 EML4-ALK FUSION GENE CUREGENE K.K. (JP) 2013-06-20 US claimed
US-20110230545-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2011-09-22 US claimed
US-20100240673-A1 EML4-ALK Fusion Gene ASTELLAS PHARMA INC. (JP) 2010-09-23 US claimed
EP-2116553-A1 EML4-ALK fusion gene Astellas Pharma Inc. (JP) 2009-11-11 EP claimed
US-20090099193-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2009-04-16 US claimed
EP-1914240-A1 EML4-ALK fusion gene Astellas Pharma Inc. (JP) 2008-04-23 EP claimed
US-20080090776-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2008-04-17 US claimed
EP-4537844-A1 PROPHYLACTIC OR THERAPEUTIC AGAINST EXACERBATION OR RECURRENCE OF CANCER, AND SCREENING METHOD THEREFOR Keio University (JP) 2025-04-16 EP disclosed
CN-119604307-A Preventive or therapeutic agent for recurrence or recurrence of cancer and screening method therefor 庆应义塾 2025-03-11 CN disclosed
WO-2023238939-A1 PROPHYLACTIC OR THERAPEUTIC AGAINST EXACERBATION OR RECURRENCE OF CANCER, AND SCREENING METHOD THEREFOR 慶應義塾 2023-12-14 WO disclosed
US-20220003771-A1 METHODS OF DETECTING A POLYPEPTIDE HAVING ANAPLASTIC LYMPHOMA KINASE ACTIVITY IN KIDNEY CANCER CELL SIGNALING TECHNOLOGY, INC. (US) 2022-01-06 US disclosed
US-20200363417-A1 METHODS OF DETECTING A POLYPEPTIDE HAVING ANAPLASTIC LYMPHOMA KINASE ACTIVITY IN KIDNEY CANCER CELL SIGNALING TECHNOLOGY, INC. (US) 2020-11-19 US disclosed
EP-2172461-A1 DI(ARYLAMINO)ARYL COMPOUND Astellas Pharma Inc. (JP) 2010-04-07 EP disclosed
EP-1914240-B1 EML4-ALK fusion gene ASTELLAS PHARMA INC (JP) 2009-12-02 EP disclosed
US-7605131-B2 EML4-ALK fusion gene ASTELLAS PHARMA INC. (JP) 2009-10-20 US disclosed
US-20090099193-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2009-04-16 US disclosed
EP-1914240-A1 EML4-ALK fusion gene Astellas Pharma Inc. (JP) 2008-04-23 EP disclosed
US-20080090776-A1 EML4-ALK FUSION GENE ASTELLAS PHARMA INC. (JP) 2008-04-17 US disclosed