Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Testosterone Propionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR known ✓ | P10275 | 4/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.98 |
| ▸ | LMNA | P02545 | 8/20 | 0.98 |
| ▸ | TSHR | P16473 | 5/20 | 0.98 |
| ▸ | MAPT | P10636 | 5/20 | 0.98 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.98 |
| ▸ | PGR | P06401 | 4/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.98 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.98 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.81 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.64 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.64 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.64 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.64 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.64 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Testosterone Propionate SCHEMBL30829229 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL18438820 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL5460173 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL8724796 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL14360596 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL25083388 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL18438872 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL21256102 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL22417524 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL4044 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108280321-B | Method for constructing anti-tumor candidate compound action mechanism prediction model based on cell metabolism contour analysis | 沈阳药科大学 | 2021-09-17 | — | — | CN | disclosed |
| CN-108280321-A | The method for building antitumor candidate compound mechanism of action prediction model based on cell metabolism edge analysis | 沈阳药科大学 | 2018-07-13 | — | — | CN | disclosed |