Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Testosterone Propionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR known ✓ | P10275 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 8/20 | 1.00 |
| ▸ | TSHR | P16473 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 4/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | CYP17A1 | P05093 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.83 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.66 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.66 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.66 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.66 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.66 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Testosterone Propionate SCHEMBL30829229 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL4044 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL18438820 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL5460173 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL14360596 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL25083388 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL18438872 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL21256102 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL22417524 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNATSHRMAPTNR3C1 | |
| Testosterone Propionate SCHEMBL28227392 | 0.99 | CYP3A4 (0.98) | CYP3A4LMNATSHRMAPTNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335545-B2 | Pharmaceutical formulations for parenteral use | UNIV FLORIDA (US) | 1998-09-23 | — | — | EP | disclosed |
| EP-0327766-B1 | Redox systems for brain-targeted drug delivery | UNIV FLORIDA (US) | 1998-04-08 | — | — | EP | disclosed |
| US-5024998-A | Administering in aqueous solution with cyclodextrin derivative | UNIVERSITY OF FLORIDA (US) | 1991-06-18 | — | — | US | disclosed |
| US-5017566-A | Redox systems for brain-targeted drug delivery | UNIVERSITY OF FLORIDA (US) | 1991-05-21 | — | — | US | disclosed |
| US-5002935-A | Inclusion Complexing Hydroxypropylcyclodextrin with a Dihydropyridine-substituted Drug | UNIVERSITY OF FLORIDA (US) | 1991-03-26 | — | — | US | disclosed |
| US-4983586-A | Decreasing precipitation at injection site or in lungs or other organs by combining with hydroxypropyl-beta-cyclodextrin | UNIVERSITY OF FLORIDA (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0335545-A2 | Pharmaceutical formulations for parenteral use | UNIVERSITY OF FLORIDA (US) | 1989-10-04 | — | — | EP | disclosed |
| EP-0327766-A2 | Redox systems for brain-targeted drug delivery | UNIVERSITY OF FLORIDA (US) | 1989-08-16 | — | — | EP | disclosed |