Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28861326 | 0.92 | BRD4 (0.44) | BRD4TLR8CNR2IKBKBBRD9 | |
| SCHEMBL28581846 | 0.76 | BRD4 (0.41) | BRD4CNR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL18584635 | 0.71 | BRD4 (0.49) | BRD4CNR2BRD9SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL18584529 | 0.70 | BRD4 (0.47) | BRD4CNR2BRD9SMN1; SMN2MEN1 | |
| SCHEMBL22341577 | 0.69 | BRD4 (0.40) | BRD4BRD9LMNAHTTKDM4E | |
| SCHEMBL251002 | 0.66 | CNR2 (0.44) | TLR8CNR2ADRA1DMEN1LMNA | |
| SCHEMBL17227678 | 0.65 | BRD4 (0.62) | BRD4CNR2SMN1; SMN2MEN1LMNA | |
| SCHEMBL7954619 | 0.63 | SMN1; SMN2 (0.39) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL3451548 | 0.63 | CNR2 (0.35) | CNR2TNFCNR1MAPT | |
| SCHEMBL29092189 | 0.62 | BRD4 (0.43) | BRD4CNR2BRD9SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108290866-A | 2- oxo -1,2- dihydropyridine -3,5- diformamide compounds as bromine structural domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2018-07-17 | — | — | CN | disclosed |