Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Imipramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 15/20 | 0.59 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.59 |
| ▸ | HRH1 | P35367 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.59 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imipramine SCHEMBL4283852 | 0.82 | SLC6A4 (0.71) | SLC6A4HRH1LMNAMAPTADORA3 | |
| Imipramine SCHEMBL2822806 | 0.81 | SLC6A4 (0.58) | SLC6A4HRH1LMNAMAPTADORA3 | |
| Imipramine SCHEMBL20644144 | 0.77 | SLC6A4 (0.83) | SLC6A4HRH1LMNAMAPTADORA3 | |
| SCHEMBL7808599 | 0.77 | SLC6A4 (0.54) | SLC6A4HRH1LMNAMAPTADORA3 | |
| Imipramine SCHEMBL6118138 | 0.77 | SLC6A4 (1.00) | SLC6A4HRH1LMNAMAPTADORA3 | |
| Imipramine SCHEMBL34282 | 0.77 | SLC6A4 (1.00) | SLC6A4HRH1LMNAMAPTADORA3 | |
| Imipramine SCHEMBL17004048 | 0.77 | SLC6A4 (1.00) | SLC6A4HRH1LMNAMAPTADORA3 | |
| Imipramine SCHEMBL29350100 | 0.77 | SLC6A4 (1.00) | SLC6A4HRH1LMNAMAPTADORA3 | |
| Imipramine SCHEMBL41765 | 0.76 | LMNA (1.00) | SLC6A4HRH1LMNAMAPTADORA3 | |
| Imipramine SCHEMBL29040915 | 0.76 | SLC6A4 (0.97) | SLC6A4HRH1LMNAMAPTADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243495-A1 | A DRUG DELIVERY SYSTEM, ITS PREPARATION PROCESS AND USE | Shenyang Pharmaceutical University (CN) | 2010-10-27 | — | — | EP | disclosed |