Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | ACP1 | P24666 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847058 | 0.81 | SIGMAR1 (0.72) | MLNRSIGMAR1CHRM3KDM4EALDH1A1 | |
| SCHEMBL29463795 | 0.81 | SIGMAR1 (0.72) | MLNRSIGMAR1CHRM3KDM4EALDH1A1 | |
| SCHEMBL27965095 | 0.81 | SIGMAR1 (0.71) | SYKSIGMAR1TP53NPC1RAB9A | |
| SCHEMBL1382022 | 0.80 | SIGMAR1 (0.70) | MLNRSIGMAR1CHRM3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7422123 | 0.80 | SIGMAR1 (0.70) | MLNRSIGMAR1CHRM3KDM4EALDH1A1 | |
| SCHEMBL28228124 | 0.79 | NPC1 (0.54) | SIGMAR1TP53NPC1RAB9ACHRM3 | |
| SCHEMBL16349084 | 0.78 | VCP (0.62) | SYKMLNRLMNACHRM3 | |
| SCHEMBL592479 | 0.78 | SIGMAR1 (0.67) | SIGMAR1SMN1; SMN2ADRB1MEN1KMT2A | |
| SCHEMBL2232773 | 0.78 | MLNR (0.53) | MLNRSIGMAR1SMN1; SMN2LMNACHRM3 | |
| SCHEMBL25549932 | 0.77 | AXL (0.63) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | claimed |
| CN-108707151-A | Pyrimido-pyridazinone compound and application thereof | 阿萨纳生物科技有限责任公司 | 2018-10-26 | — | — | CN | claimed |
| CN-108601785-A | Purposes of the pyrimido pyridazinone in treating cancer | 阿沙纳生物科学公司 | 2018-09-28 | — | — | CN | claimed |
| CN-103974955-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2018-06-19 | — | — | CN | claimed |
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-108707151-A | Pyrimido-pyridazinone compound and application thereof | 阿萨纳生物科技有限责任公司 | 2018-10-26 | — | — | CN | disclosed |