Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24534132 | 0.84 | HCAR2 (0.52) | MKNK1MKNK2KDM4EMEN1ALDH1A1 | |
| SCHEMBL24534031 | 0.79 | ATM (0.54) | CYP11B2CYP11B1KDM4EALDH1A1ALPL | |
| SCHEMBL7666563 | 0.78 | CYP11B1 (0.49) | CYP11B2CYP11B1MKNK1MKNK2SIRT2 | |
| SCHEMBL509510 | 0.78 | CYP11B2 (0.49) | CYP11B2CYP11B1MKNK1MKNK2SIRT2 | |
| SCHEMBL18340498 | 0.78 | CYP11B2 (0.49) | CYP11B2CYP11B1MKNK1MKNK2SIRT2 | |
| SCHEMBL9607829 | 0.77 | SMYD3 (0.52) | CYP11B2CYP11B1MKNK1MKNK2SIRT2 | |
| SCHEMBL28999567 | 0.77 | CYP11B1 (0.48) | CYP11B2CYP11B1MKNK1MKNK2SIRT2 | |
| SCHEMBL31046827 | 0.77 | SMYD3 (0.52) | CYP11B2CYP11B1MKNK1MKNK2SIRT2 | |
| SCHEMBL30281191 | 0.76 | CYP11B2 (0.45) | CYP11B2CYP11B1DDR1DDR2MKNK1 | |
| SCHEMBL30827012 | 0.75 | CYP11B1 (0.47) | CYP11B2CYP11B1MKNK1MKNK2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108349944-A | INDOLIN-2-ONE DERIVATIVES | 豪夫迈·罗氏有限公司 | 2018-07-31 | — | — | CN | disclosed |