Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 8/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL509510 | 0.84 | CYP11B2 (0.49) | CYP11B1CYP11B2SIRT2SIRT3SIRT1 | |
| SCHEMBL18340498 | 0.84 | CYP11B2 (0.49) | CYP11B1CYP11B2SIRT2SIRT3SIRT1 | |
| SCHEMBL31046827 | 0.82 | SMYD3 (0.52) | CYP11B1CYP11B2SIRT2SIRT3SIRT1 | |
| SCHEMBL28999567 | 0.82 | CYP11B1 (0.48) | CYP11B1CYP11B2SIRT2SIRT3SIRT1 | |
| SCHEMBL9607829 | 0.82 | SMYD3 (0.52) | CYP11B1CYP11B2SIRT2SIRT3SIRT1 | |
| SCHEMBL7674347 | 0.82 | HCAR2 (0.53) | CYP11B1CYP11B2MKNK1MKNK2RAF1 | |
| SCHEMBL30827012 | 0.81 | CYP11B1 (0.47) | CYP11B1CYP11B2SIRT2SIRT3SIRT1 | |
| Hydrochloric Acid SCHEMBL29793528 | 0.81 | SMYD3 (0.51) | CYP11B1CYP11B2SIRT2SIRT3SIRT1 | |
| SCHEMBL2841794 | 0.80 | SIRT2 (0.54) | CYP11B1CYP11B2SIRT2SIRT3SIRT1 | |
| SCHEMBL24252516 | 0.78 | CYP11B1 (0.45) | CYP11B1CYP11B2SIRT2SIRT3SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| CN-1284075-A | Novel compounds having CGMP-PDE inhibitory effect | MOCHIDA PHARM CO LTD (JP) | 2001-02-14 | — | — | CN | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |