Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28137206 | 0.92 | MAPT (0.60) | CA2MAPK1MAPTGPR84FFAR1 | |
| SCHEMBL5859388 | 0.78 | CA2 (0.56) | CA2MAPK1MAPTCA1GPR84 | |
| SCHEMBL11440612 | 0.77 | CA2 (0.54) | CA2MAPK1MAPTCA1GPR84 | |
| SCHEMBL11809231 | 0.77 | CA2 (0.54) | CA2MAPK1MAPTCA1GPR84 | |
| SCHEMBL10578859 | 0.75 | CA2 (0.52) | CA2MAPK1MAPTCA1GPR84 | |
| SCHEMBL29634861 | 0.75 | CA2 (0.52) | CA2MAPK1MAPTCA1GPR84 | |
| SCHEMBL4774070 | 0.75 | CA2 (0.52) | CA2MAPK1MAPTCA1GPR84 | |
| Ammonia Solution, Strong SCHEMBL28495167 | 0.75 | MAPT (0.48) | CA2MAPK1MAPTCA1GPR84 | |
| SCHEMBL27637001 | 0.75 | CA2 (0.52) | CA2MAPK1MAPTCA1GPR84 | |
| SCHEMBL2269027 | 0.73 | CA2 (0.50) | CA2MAPK1MAPTGPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108349988-A | tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitor | 卡鲁斯治疗有限公司 | 2018-07-31 | — | — | CN | disclosed |