Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29634861 | 1.00 | CA2 (0.52) | CA2MAPK1SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL27637001 | 1.00 | CA2 (0.52) | CA2MAPK1SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL21981372 | 0.88 | SLC1A2 (0.48) | CA2MAPK1SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL7055852 | 0.87 | CHRM1 (0.46) | CA2MAPK1SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL21054364 | 0.86 | GSR (0.45) | CA2MAPK1SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL21054367 | 0.86 | GSR (0.45) | CA2MAPK1SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL2983833 | 0.85 | GRIK1 (0.53) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| SCHEMBL7053586 | 0.85 | CHRM1 (0.44) | CA2MAPK1SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL3100665 | 0.85 | GRIK1 (0.53) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| SCHEMBL2983835 | 0.85 | GRIK1 (0.53) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585749-B1 | DIAZEPINOINDOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1947102-A1 | Compositions comprising diazepinoindole derivatives as kinase inhibitors | Pfizer, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| CN-1759118-A | Diazepinoindole derivatives as kinase inhibitors | PFIZER (US) | 2006-04-12 | — | — | CN | disclosed |