Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053217 | 0.85 | CYP11B2 (0.42) | PDE4BADORA2AADORA2BADORA1TBXAS1 | |
| SCHEMBL2824627 | 0.81 | PDE4B (0.53) | PDE4BADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL8443792 | 0.81 | MEN1 (0.44) | PDE4BKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL4059984 | 0.80 | TBXAS1 (0.56) | PDE4BADORA2AADORA2BADORA1TBXAS1 | |
| SCHEMBL4053231 | 0.77 | AURKB (0.48) | PDE4BADORA2AADORA1TBXAS1KDM4E | |
| SCHEMBL4053270 | 0.76 | SMN1; SMN2 (0.49) | PDE4BADORA2AADORA1TBXAS1MAPT | |
| SCHEMBL4055324 | 0.74 | GAA (0.49) | KDM4EMAPTL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL4062839 | 0.74 | PRMT5 (0.36) | PDE4BADORA2AADORA2BADORA1TBXAS1 | |
| SCHEMBL4054889 | 0.73 | PDE4B (0.44) | PDE4BADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL2822304 | 0.73 | PDE4B (0.80) | PDE4BADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |