Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823667 | 1.00 | MAPK1 (0.51) | MAPK1SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2830607 | 0.86 | MAPK1 (0.46) | MAPK1SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2830605 | 0.86 | MAPK1 (0.46) | MAPK1SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL13935128 | 0.85 | MAPK1 (0.45) | MAPK1SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL13935129 | 0.85 | MAPK1 (0.45) | MAPK1SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2824779 | 0.85 | MAPK1 (0.48) | MAPK1SMN1; SMN2ALDH1A1RXFP1RAB9A | |
| SCHEMBL2824778 | 0.85 | MAPK1 (0.48) | MAPK1SMN1; SMN2ALDH1A1RXFP1RAB9A | |
| SCHEMBL2822485 | 0.84 | MAPK1 (0.44) | MAPK1SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2822488 | 0.84 | MAPK1 (0.44) | MAPK1SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2827667 | 0.76 | MAPK1 (0.48) | MAPK1SMN1; SMN2CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318928-B2 | Fused imidazole carboxamides as TRPV3 modulators | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2012-11-27 | — | — | US | disclosed |
| US-20100152192-A1 | FUSED IMIDAZOLE CARBOXAMIDES AS TRPV3 MODULATORS | GLENMARK PHARMACEUTICALS S.A (CH) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152192-A1 | FUSED IMIDAZOLE CARBOXAMIDES AS TRPV3 MODULATORS | TRPV3, TRPV1, TRPV2 | MAPK1 2141/4885SMN1; SMN2 3907/4885CYP1A2 1594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.