Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gsk-1004723. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 19/20 | 1.00 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 17/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 19/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 18/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 8/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | HRH2 | P25021 | 2/20 | 1.00 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gsk-1004723 SCHEMBL986140 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Gsk-1004723 SCHEMBL2819051 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2820953 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL22847921 | 0.93 | HRH3 (0.88) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2820304 | 0.93 | ADRA1A (0.86) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2820231 | 0.93 | HRH1 (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2820984 | 0.93 | HRH1 (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2821550 | 0.92 | HRH1 (0.86) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2818951 | 0.92 | HRH1 (0.86) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2820146 | 0.91 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007735-B1 | 2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-10-27 | — | — | EP | disclosed |
| US-20090105225-A1 | 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | US | disclosed |
| WO-2009050159-A1 | COMBINATION OF FLUTICASONE FUROATE WITH 4- [ (4-CHL0R0PHENYL)METHYL] -2- ({ (2R)-I- [4-(4-{ [3-(HEXAHYDR0-LH-AZEPIN-L-YL) PROPYL ] OXY} PHENYL) BUTYL] -2-PYRROLIDINYL}METHYL) -1 (2H) - PHTHALAZ INONE | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |
| US-20080039444-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039444-A1 | COMPOUNDS | CMA1, MRGPRX2, HRH2 | HRH1 4/4885HRH3 16/4885ADRA1A 362/4885 |
| US-20090105225-A1 | 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists | HRH2, HRH3, HRH4 | HRH1 4/4885HRH3 2/4885ADRA1A 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.