Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5832224 | 0.89 | APLNR (0.59) | APLNRCA12CA1CA2CA7 | |
| SCHEMBL30107392 | 0.89 | APLNR (0.63) | APLNRCA12CA1CA2CA7 | |
| SCHEMBL9417780 | 0.84 | APLNR (0.58) | APLNRCA12CA1CA2CA7 | |
| SCHEMBL30092258 | 0.82 | APLNR (0.56) | APLNRCA12CA1CA2CA7 | |
| SCHEMBL22939735 | 0.82 | APLNR (0.56) | APLNRHTR2AALDH1A1 | |
| SCHEMBL80130 | 0.82 | APLNR (0.56) | APLNRCA12CA1CA2CA7 | |
| SCHEMBL81884 | 0.82 | APLNR (0.56) | APLNRCA12CA1CA2CA7 | |
| SCHEMBL840382 | 0.81 | APLNR (0.63) | APLNRCA12CA1CA2CA7 | |
| SCHEMBL1171776 | 0.81 | MEN1 (0.56) | APLNRHTR2AALDH1A1 | |
| SCHEMBL30358658 | 0.81 | MEN1 (0.56) | APLNRHTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108513574-A | N-sulfonylated pyrazolo [3,4-b ] pyridine-6-carboxamides and methods of use | 艾伯维公司 | 2018-09-07 | — | — | CN | disclosed |
| CN-108431002-A | Substituted pyrazolo [3, 4-b ] pyridine-6-carboxylic acids and uses thereof | 艾伯维公司 | 2018-08-21 | — | — | CN | disclosed |