Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.35 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL29674668 | 0.81 | TP53 (0.61) | TP53RNPEPCYP1A2 | |
| Lactic Acid SCHEMBL1237356 | 0.81 | TP53 (0.61) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Lactic Acid SCHEMBL28158391 | 0.81 | TP53 (0.61) | TP53ALDH1A1RNPEP | |
| Lactic Acid SCHEMBL5697792 | 0.80 | TP53 (0.69) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Lactic Acid SCHEMBL15313316 | 0.80 | TP53 (0.69) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Lactic Acid SCHEMBL2829118 | 0.80 | — | — | |
| Lactic Acid SCHEMBL27721040 | 0.80 | — | — | |
| Lactic Acid SCHEMBL1065355 | 0.80 | — | — | |
| Lactic Acid SCHEMBL1954971 | 0.80 | TP53 (0.92) | TP53ALDH1A1 | |
| Lactic Acid SCHEMBL1229318 | 0.80 | TP53 (0.92) | TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105874017-B | The method for being used to prepare the formulation comprising pigment and filler | 巴斯夫涂料有限公司 | 2018-08-28 | — | — | CN | disclosed |