Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.54 |
| ▸ | GABRD | O14764 | 2/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.54 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.54 |
| ▸ | GABRE | P78334 | 2/20 | 0.54 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.54 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.54 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.54 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19808801 | 0.87 | TDP1 (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28245974 | 0.86 | F10 (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL19808926 | 0.84 | GABRP (0.47) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL19808866 | 0.82 | EGLN1 (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL24195300 | 0.81 | TDP1 (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28865211 | 0.76 | MCL1 (0.47) | MCL1BAK1F10POLBTDP1 | |
| SCHEMBL28245897 | 0.76 | HTT (0.40) | KDM4ENPC1RAB9ATDP1MEN1 | |
| SCHEMBL12082701 | 0.76 | P2RX3 (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL19808886 | 0.75 | TDP1 (0.48) | KDM4ENPC1RAB9ATDP1ALDH1A1 | |
| SCHEMBL19808814 | 0.75 | KDM4E (0.44) | KDM4ENPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146490-B | 5- hydroxyl -1,7- naphthyridine compounds, preparation method and its pharmaceutical applications replaced by aryloxy group or heteroaryloxy | 沈阳三生制药有限责任公司 | 2018-10-23 | — | — | CN | disclosed |