Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.47 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823410 | 1.00 | HSD11B1 (0.47) | HSD11B1HSD11B2POLBCNR2MAPK1 | |
| SCHEMBL2823390 | 0.90 | HSD11B1 (0.38) | HSD11B1HSD11B2MAPK1ALDH1A1RAB9A | |
| SCHEMBL2823391 | 0.90 | HSD11B1 (0.38) | HSD11B1HSD11B2MAPK1ALDH1A1RAB9A | |
| SCHEMBL2823676 | 0.86 | HSD11B1 (0.52) | HSD11B1HSD11B2EPHX2USP30 | |
| SCHEMBL2823671 | 0.86 | HSD11B1 (0.52) | HSD11B1HSD11B2EPHX2USP30 | |
| SCHEMBL2824910 | 0.84 | HSD11B1 (0.45) | HSD11B1HSD11B2MAPK1ALDH1A1RAB9A | |
| SCHEMBL2824905 | 0.84 | HSD11B1 (0.45) | HSD11B1HSD11B2MAPK1ALDH1A1RAB9A | |
| SCHEMBL2827919 | 0.82 | HSD11B1 (0.40) | HSD11B1HSD11B2MAPK1ALDH1A1KMT2A | |
| SCHEMBL2827916 | 0.82 | HSD11B1 (0.40) | HSD11B1HSD11B2MAPK1ALDH1A1KMT2A | |
| SCHEMBL2827933 | 0.81 | HSD11B1 (0.56) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |