Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 5/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823390 | 1.00 | HSD11B1 (0.38) | HSD11B1HSD11B2EPHX2KMT2ARAB9A | |
| SCHEMBL2823410 | 0.90 | HSD11B1 (0.47) | HSD11B1HSD11B2EPHX2KMT2ARAB9A | |
| SCHEMBL2824618 | 0.90 | HSD11B1 (0.47) | HSD11B1HSD11B2EPHX2KMT2ARAB9A | |
| SCHEMBL2823970 | 0.81 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL2823974 | 0.81 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL2824476 | 0.81 | NPC1 (0.40) | HSD11B1KMT2ARAB9AALDH1A1 | |
| SCHEMBL2824480 | 0.81 | NPC1 (0.40) | HSD11B1KMT2ARAB9AALDH1A1 | |
| SCHEMBL2824721 | 0.80 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL2824714 | 0.80 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL2823394 | 0.79 | SIGMAR1 (0.38) | HSD11B1HSD11B2KMT2ASLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |