Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 3/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 6/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | BHMT | Q93088 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL28467895 | 0.95 | GRIK1 (0.44) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Leucine SCHEMBL27822812 | 0.88 | SLC7A5 (0.49) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Glutamic Acid SCHEMBL31454133 | 0.88 | SLC1A2 (0.49) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| D-Glutamate SCHEMBL28179361 | 0.88 | SLC1A2 (0.49) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Serine SCHEMBL30913268 | 0.87 | SLC1A2 (0.43) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Serine SCHEMBL28100327 | 0.87 | SLC1A2 (0.43) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Cysteine SCHEMBL28327990 | 0.86 | PTGS1 (0.44) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Alanine SCHEMBL29898525 | 0.85 | SLC15A1 (0.41) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Alanine SCHEMBL27893492 | 0.85 | SLC15A1 (0.41) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Lysine SCHEMBL27898144 | 0.85 | GSR (0.54) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106220566-B | Ionic liquid with amino acid and preparation method and application thereof | 辽宁大学 | 2019-02-19 | — | — | CN | claimed |
| CN-108794400-B | Amino acid-containing ionic liquid with amino group on cation, and preparation method and application thereof | 辽宁大学 | 2021-06-25 | — | — | CN | disclosed |
| CN-106220566-B | Ionic liquid with amino acid and preparation method and application thereof | 辽宁大学 | 2019-02-19 | — | — | CN | disclosed |
| CN-108794400-A | A kind of ionic liquid and its preparation method and application containing amino acid of the cation with amino | 辽宁大学 | 2018-11-13 | — | — | CN | disclosed |