Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066901 | 0.88 | MTNR1A (0.50) | MTNR1AMTNR1BALDH1A1KDM4EOPRL1 | |
| SCHEMBL5380872 | 0.88 | MTNR1A (0.50) | MTNR1AMTNR1BALDH1A1KDM4EOPRL1 | |
| SCHEMBL28248972 | 0.88 | MTNR1A (0.41) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| Hydrochloric Acid SCHEMBL28260890 | 0.86 | MTNR1A (0.40) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| SCHEMBL28249001 | 0.84 | MTNR1A (0.44) | MTNR1AMTNR1BOPRL1OPRM1 | |
| SCHEMBL9240061 | 0.77 | MTNR1A (0.51) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| SCHEMBL28249002 | 0.76 | MTNR1A (0.38) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| SCHEMBL28260913 | 0.75 | MTNR1A (0.37) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| SCHEMBL11146721 | 0.75 | MTNR1A (0.47) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| SCHEMBL5370015 | 0.74 | MTNR1A (0.56) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | claimed |
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108884106-A | POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE | 詹森药业有限公司 | 2018-11-23 | — | — | CN | disclosed |